Calvert Hall senior Chance Campbell scored two touchdowns, recorded two sacks and pulled down an interception in the Cardinals' 27-6 win over rival Loyola in the 98th annual Turkey Bowl.
Senior Evan Boozer scored the Dons' lone touchdown.
The game was played at Towson University's Johnny Unitas Stadium.
Calvert Hall has won four consecutive Turkey Bowls and eight of the last nine.